Pair bonding mammals  appear to be more susceptible to substance addictions than other mammals – unless they have already pair-bonded. An established pair bond can actually ease addiction risk by making an artificial competing “high” comparatively less appealing.

This means that forming and sustaining healthy pair bonds makes sense as a top priority in today’s enticement-heavy environment. At the same time, it means that those who haven’t yet formed pair bonds are vulnerable to getting hooked on artificial substitutes – and perhaps ultimately finding real relationships less rewarding in comparison.

It would be well to investigate whether online erotica, sex toys, dating apps and other artificial stimuli have the potential to interfere with human pair bonds at a neurobiological level. Already there are dozens of studies correlating the use of such stimuli with reduced sexual and relationship satisfaction.

The research below provides examples of the pair-bonding mechanism, its protective gifts, and its vulnerabilities. It appears that the neurochemical oxytocin plays a role, at least in men.

Dr. Heike Melzer discusses the issue of competing stimuli in this TEDx talk. Click “CC” to turn on subtitles.


Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Alcohol’s Effects on Pair-Bond Maintenance in Male Prairie Voles

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

The behavioral anatomical and pharmacological parallels between social attachment love and addiction

Amphetamine reward in the monogamous prairie vole

Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

Biological Contribution to Social Influences on Alcohol Drinking: Evidence from Animal Models

Influences of social reward experience on behavioral responses to drugs of abuse: Review of shared and divergent neural plasticity mechanisms for sexual reward and drugs of abuse

Pair-bonding animal model for testing and treatment

Prairie Voles as a Model to Screen Medications for the Treatment of Alcoholism and Addictions

Amphetamine effects in microtine rodents: a comparative study using monogamous and promiscuous vole species